Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects

ALS Motor Neurons Differ by Sex, Study Finds. A new Cedars-Sinai study in collaboration with the University of California, Irvine (UCI) and the Answer ALS consortium has examined the expression of thousands of genes in stem cell-generated motor neurons that are known to die in patients with ALS.

The study, published in the peer-reviewed journal Neuron, revealed sex was one of the main drivers of different gene expression in motor neurons, regardless of whether they were from patients diagnosed with ALS or controls. Read the entire study here: http://bit.ly/3J6yldG

Latest News
 
Answer ALS Data Sets Featured in GNPC Proteomics Data Challenge on AD Workbench

NEW ORLEANS, November 19, 2025: Alzheimer’s Disease Data Initiative (ADDI) has opened applications...

 
Answer ALS Completes Release of Full Dataset and Integrates ALS TDI ARC Study Data into Neuromine

All data from 1,100+ Answer ALS participants, including ALS TDI’s ARC study data, are now harmoniz...

 
United for Answers: Leading ALS Organizations Announce ‘Champion Insights’ to Unlock Why Athletes and Military Members Face Higher ALS Risk

State-of-the-art remote-participation research seeks to understand how genetic factors linked to int...